Jenee, it's been a little while since I've been, so it may have changed, but they do carry lines like Bare Escentuals, Smashbox, Cargo and Plantlove, Anastasia, Benefit (plus a Brow Bar), Nars, plus all the usual department store brands (and they carry EL, which Sephora doesn't, and I think Chanel). They also have Bobbi Brown. They don't have Stila, TheBalm or the Sephora-partnered brands like Kat von D. They had a couple of brands that I haven't found anywhere else, like Mommy Makeup and some of the brands they feature in SDM stores, like Gosh and No7.
I don't think they have Kevyn Aucoin, Givenchy or YSL, but like I said, I haven't been in a while.
It's worth taking a trip out to see if you have one near you. I've worked for Sephora and I think they are fairly similar - Sephora does have more cosmetic brands (at least ones that I like), whereas Murale has an advantage is maybe the overall higher-end, zen feel, but since the SAs work on commission there is a bit more pressure to buy. (And I really envied them for being able to wear more fashiony, regular clothes, as opposed to the ridiculous Romulan space suit we had to at Sephora.)
I wouldn't shop there primarily, but if I have Optimum Points to burn or they have a good promo going, I would go there for the Bobbi Brown or Lipmann stuff.
They also have a lot more skincare brands than Sephora, I think.