Any bite is annoying, but the worst I've had were on the face and on the butt (sitting on it irritates it and causes more itching). Ankle bites don't compare to how irritating those are.
This past weekend I got an ant bite on my eyelid while I was sleeping. And 7 more down my left arm that were severely swollen, throbbing with pain and making me lightheaded.
Ice packs work best for me. If it's really bad (like yesterday) I might take some Benadryl. There's all sorts of topical treatments you could use like calamine lotion, hydrocortisone cream, Afterbite (active ingredient is ammonia and it does smell).