Technically you could put it on right away, but I don't think you'll want to. I had my first (and thus far only!) facial a few months ago, and I had makeup with me for afterwards. When she was done I went to get dressed and reMAC, but I looked in the mirror and my skin was so red and all my pores so irritated from the pore extraction that I was just like, "f*** it, there's no point," and let my skin rest and heal. I'd just wait until the next day, especially if you have oily and blemished skin, because they're going to give it a good workout!